STK11
serine/threonine kinase 11 | LKB1, PJS

The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers. [provided by RefSeq, May 2022]

Biological processes 86 terms
ATP binding (GO:0005524)ATP binding (GO:0005524)DNA damage response (GO:0006974)DNA damage response (GO:0006974)DNA damage response (GO:0006974)G1 to G0 transition (GO:0070314)G1 to G0 transition (GO:0070314)LRR domain binding (GO:0030275)activation of protein kinase activity (GO:0032147)activation of protein kinase activity (GO:0032147)anoikis (GO:0043276)axonogenesis (GO:0007409)cellular response to UV-B (GO:0071493)cellular response to UV-B (GO:0071493)cellular response to glucose starvation (GO:0042149)cellular response to glucose starvation (GO:0042149)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)establishment of cell polarity (GO:0030010)establishment of cell polarity (GO:0030010)establishment of cell polarity (GO:0030010)establishment of cell polarity (GO:0030010)extracellular exosome (GO:0070062)glucose homeostasis (GO:0042593)glucose homeostasis (GO:0042593)intracellular protein-containing complex (GO:0140535)intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332)late endosome (GO:0005770)late endosome (GO:0005770)magnesium ion binding (GO:0000287)membrane (GO:0016020)membrane (GO:0016020)mitochondrion (GO:0005739)mitochondrion (GO:0005739)negative regulation of TORC1 signaling (GO:1904262)negative regulation of TORC1 signaling (GO:1904262)negative regulation of canonical Wnt signaling pathway (GO:0090090)negative regulation of cell growth (GO:0030308)negative regulation of cell growth (GO:0030308)negative regulation of cell population proliferation (GO:0008285)negative regulation of cell population proliferation (GO:0008285)negative regulation of cold-induced thermogenesis (GO:0120163)negative regulation of cold-induced thermogenesis (GO:0120163)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)p53 binding (GO:0002039)peptidyl-threonine phosphorylation (GO:0018107)positive regulation of autophagy (GO:0010508)positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)positive regulation of vesicle transport along microtubule (GO:1901610)positive regulation of vesicle transport along microtubule (GO:1901610)positive regulation of vesicle transport along microtubule (GO:1901610)protein autophosphorylation (GO:0046777)protein binding (GO:0005515)protein dephosphorylation (GO:0006470)protein kinase activator activity (GO:0030295)protein kinase activator activity (GO:0030295)protein kinase activator activity (GO:0030295)protein kinase activity (GO:0004672)protein phosphorylation (GO:0006468)protein phosphorylation (GO:0006468)protein serine kinase activity (GO:0106310)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)regulation of Wnt signaling pathway (GO:0030111)regulation of cell cycle (GO:0051726)regulation of cell growth (GO:0001558)regulation of cell growth (GO:0001558)regulation of signal transduction by p53 class mediator (GO:1901796)response to ionizing radiation (GO:0010212)response to ionizing radiation (GO:0010212)signal transduction (GO:0007165)vasculature development (GO:0001944)vasculature development (GO:0001944)
Expression (TPM)
STK11 — as a Regulated Gene

TFs regulating STK11 0 TFs

Transcription factors with Perturb-seq knockdown data for STK11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STK11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to STK11

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STK11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:917,038–918,169 287.9 kb Distal (>10kb) Multiome 711
chr19:924,743–926,242 280.1 kb Distal (>10kb) Multiome 796
chr19:927,058–927,629 278.4 kb Distal (>10kb) Multiome 362
chr19:982,565–983,215 222.9 kb Distal (>10kb) Multiome 590
chr19:984,046–985,154 221.3 kb Distal (>10kb) Multiome 829
chr19:1,000,142–1,000,881 205.4 kb Distal (>10kb) Multiome HiCAR 399
chr19:1,020,611–1,022,069 184.4 kb Distal (>10kb) Multiome HiCAR 1017
chr19:1,026,155–1,026,856 179.3 kb Distal (>10kb) Multiome HiCAR 598
chr19:1,027,770–1,028,926 177.2 kb Distal (>10kb) Multiome HiCAR 584
chr19:1,039,648–1,040,400 165.8 kb Distal (>10kb) Multiome 684
chr19:1,040,481–1,041,402 164.6 kb Distal (>10kb) Multiome 556
chr19:1,044,758–1,045,598 160.4 kb Distal (>10kb) Multiome 402
chr19:1,061,840–1,062,923 143.2 kb Distal (>10kb) Multiome HiCAR 204
chr19:1,063,045–1,065,722 140.9 kb Distal (>10kb) Multiome HiCAR 681
chr19:1,066,682–1,067,587 138.5 kb Distal (>10kb) Multiome HiCAR 489
chr19:1,071,107–1,071,721 134.6 kb Distal (>10kb) Multiome 178
chr19:1,081,317–1,083,172 123.3 kb Distal (>10kb) Multiome 484
chr19:1,094,985–1,095,654 110.3 kb Distal (>10kb) Multiome HiCAR 671
chr19:1,103,487–1,105,654 101.8 kb Distal (>10kb) Multiome HiCAR 849
chr19:1,112,029–1,112,884 93.5 kb Distal (>10kb) Multiome HiCAR 294
chr19:1,113,014–1,114,139 92.2 kb Distal (>10kb) Multiome HiCAR 690
chr19:1,122,934–1,123,720 82.5 kb Distal (>10kb) Multiome HiCAR 231
chr19:1,173,441–1,174,438 31.5 kb Distal (>10kb) Multiome 682
chr19:1,194,370–1,194,985 11.1 kb Distal (>10kb) Multiome 531
chr19:1,205,175–1,206,374 164 bp At TSS Multiome 746
chr19:1,237,080–1,238,434 32.3 kb Distal (>10kb) Multiome 430
chr19:1,239,513–1,242,539 36.0 kb Distal (>10kb) Multiome 889
chr19:1,244,253–1,244,857 38.8 kb Distal (>10kb) Multiome 590
chr19:1,247,981–1,252,501 45.3 kb Distal (>10kb) Multiome 1136
chr19:1,259,185–1,262,955 53.6 kb Distal (>10kb) Multiome 1070
chr19:1,265,280–1,270,235 63.5 kb Distal (>10kb) Multiome 1171
chr19:1,274,423–1,276,502 70.0 kb Distal (>10kb) Multiome 967
chr19:1,285,317–1,286,108 80.0 kb Distal (>10kb) Multiome 277
chr19:1,354,303–1,355,411 149.1 kb Distal (>10kb) Multiome 688
chr19:1,383,122–1,384,333 177.9 kb Distal (>10kb) Multiome 1228
chr19:1,401,101–1,401,839 195.8 kb Distal (>10kb) Multiome 540
chr19:1,406,589–1,408,783 201.7 kb Distal (>10kb) Multiome 911
chr19:1,415,008–1,415,721 209.7 kb Distal (>10kb) Multiome 597
chr19:1,437,988–1,438,998 232.6 kb Distal (>10kb) Multiome 1076
chr19:1,444,785–1,447,383 239.5 kb Distal (>10kb) Multiome 797
chr19:1,455,191–1,456,421 250.0 kb Distal (>10kb) Multiome 491
chr19:1,468,941–1,469,903 263.5 kb Distal (>10kb) Multiome 242
chr19:1,470,088–1,471,597 265.0 kb Distal (>10kb) Multiome 544
chr19:1,478,772–1,479,848 273.6 kb Distal (>10kb) Multiome 857
chr19:1,489,566–1,491,829 285.1 kb Distal (>10kb) Multiome 836

Genome Browser

Genomic view of the STK11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:907,038 – 1,501,829
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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