This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for STK10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STK10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STK10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:172,005,757–172,007,902 | 181.4 kb | Distal (>10kb) Multiome | 919 | |
| chr5:172,008,642–172,009,211 | 179.3 kb | Distal (>10kb) Multiome | 162 | |
| chr5:172,106,761–172,107,159 | at TSS | At TSS | 343 | |
| chr5:172,178,293–172,178,672 | 9.6 kb | Proximal (<10kb) | 177 | |
| chr5:172,178,773–172,179,236 | 9.0 kb | Proximal (<10kb) | 92 | |
| chr5:172,187,117–172,188,967 | 247 bp | At TSS Multiome | 988 | |
| chr5:172,189,397–172,189,742 | 1.2 kb | Proximal (<10kb) | 80 | |
| chr5:172,282,945–172,284,922 | 95.8 kb | Distal (>10kb) Multiome | 857 | |
| chr5:172,453,197–172,453,607 | 265.0 kb | Distal (>10kb) Multiome | 249 | |
| chr5:172,453,730–172,456,312 | 266.4 kb | Distal (>10kb) Multiome | 677 | |
| chr5:172,478,999–172,479,594 | 291.0 kb | Distal (>10kb) Multiome | 365 |
Genomic view of the STK10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.