Enables calcium channel regulator activity. Involved in activation of store-operated calcium channel activity and store-operated calcium entry. Located in cortical endoplasmic reticulum; endoplasmic reticulum membrane; and endoplasmic reticulum-plasma membrane contact site. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STIMATE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STIMATE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STIMATE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:52,685,427–52,686,463 | 211.7 kb | Distal (>10kb) Multiome | 933 | |
| chr3:52,705,495–52,706,415 | 191.6 kb | Distal (>10kb) Multiome | 862 | |
| chr3:52,714,354–52,715,301 | 182.9 kb | Distal (>10kb) Multiome | 224 | |
| chr3:52,770,467–52,771,332 | 126.7 kb | Distal (>10kb) Multiome | 788 | |
| chr3:52,897,094–52,897,995 | 62 bp | At TSS Multiome | 474 | |
| chr3:53,044,987–53,047,058 | 147.9 kb | Distal (>10kb) Multiome | 653 | |
| chr3:53,072,497–53,073,757 | 175.4 kb | Distal (>10kb) Multiome HiCAR | 597 | |
| chr3:53,130,008–53,130,811 | 232.9 kb | Distal (>10kb) Multiome | 781 | |
| chr3:53,160,572–53,162,503 | 263.4 kb | Distal (>10kb) Multiome | 627 |
Genomic view of the STIMATE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.