This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009]
Transcription factors with Perturb-seq knockdown data for STIM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STIM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STIM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:26,583,577–26,584,548 | 276.8 kb | Distal (>10kb) Multiome | 965 | |
| chr4:26,857,192–26,858,131 | 3.1 kb | Proximal (<10kb) Multiome | 772 | |
| chr4:26,858,286–26,858,600 | 686 bp | At TSS | 127 | |
| chr4:26,859,867–26,862,050 | 128 bp | At TSS Multiome | 911 | |
| chr4:26,866,137–26,866,654 | 8.5 kb | Proximal (<10kb) | 14 | |
| chr4:26,866,934–26,867,099 | 9.3 kb | Proximal (<10kb) | 35 | |
| chr4:27,084,230–27,085,240 | 224.0 kb | Distal (>10kb) Multiome | 310 | |
| chr4:27,121,777–27,123,831 | 262.6 kb | Distal (>10kb) Multiome | 326 |
Genomic view of the STIM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.