Transcription factors with Perturb-seq knockdown data for ST8SIA6-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST8SIA6-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST8SIA6-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:16,816,770–16,818,262 | 569.4 kb | Distal (>10kb) Multiome HiCAR | 801 | |
| chr10:17,200,899–17,202,136 | 185.4 kb | Distal (>10kb) Multiome | 1040 | |
| chr10:17,228,175–17,230,908 | 157.9 kb | Distal (>10kb) Multiome | 920 | |
| chr10:17,377,105–17,377,326 | 9.6 kb | Proximal (<10kb) | 16 | |
| chr10:17,377,887–17,378,221 | 8.7 kb | Proximal (<10kb) | 16 | |
| chr10:17,378,752–17,378,926 | 8.0 kb | Proximal (<10kb) | 1 | |
| chr10:17,379,036–17,380,059 | 7.5 kb | Proximal (<10kb) Multiome | 120 | |
| chr10:17,382,489–17,382,747 | 4.2 kb | Proximal (<10kb) | 7 | |
| chr10:17,386,761–17,387,021 | at TSS | At TSS | 141 | |
| chr10:17,387,758–17,388,950 | 1.4 kb | Proximal (<10kb) Multiome | 319 | |
| chr10:17,453,122–17,455,034 | 67.5 kb | Distal (>10kb) Multiome | 584 | |
| chr10:17,616,423–17,618,050 | 230.5 kb | Distal (>10kb) Multiome | 800 | |
| chr10:17,643,443–17,644,922 | 257.2 kb | Distal (>10kb) Multiome | 877 | |
| chr10:17,673,416–17,674,078 | 286.9 kb | Distal (>10kb) Multiome | 368 |
Genomic view of the ST8SIA6-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.