This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for ST8SIA6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST8SIA6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST8SIA6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:17,200,899–17,202,136 | 252.6 kb | Distal (>10kb) Multiome | 1040 | |
| chr10:17,228,175–17,230,908 | 225.2 kb | Distal (>10kb) Multiome | 920 | |
| chr10:17,379,036–17,380,059 | 74.8 kb | Distal (>10kb) Multiome | 120 | |
| chr10:17,387,758–17,388,950 | 65.9 kb | Distal (>10kb) Multiome | 319 | |
| chr10:17,452,026–17,452,580 | 1.6 kb | Proximal (<10kb) | 129 | |
| chr10:17,453,122–17,455,034 | 226 bp | At TSS Multiome | 584 | |
| chr10:17,455,093–17,455,455 | 897 bp | At TSS | 158 | |
| chr10:17,616,423–17,618,050 | 163.2 kb | Distal (>10kb) Multiome | 800 | |
| chr10:17,643,443–17,644,922 | 189.9 kb | Distal (>10kb) Multiome | 877 | |
| chr10:17,673,416–17,674,078 | 219.6 kb | Distal (>10kb) Multiome | 368 |
Genomic view of the ST8SIA6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.