Transcription factors with Perturb-seq knockdown data for ST7-OT4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST7-OT4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST7-OT4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:116,951,562–116,951,930 | 2.0 kb | Proximal (<10kb) | 165 | |
| chr7:116,952,833–116,954,651 | at TSS | At TSS | 944 | |
| chr7:116,958,004–116,958,328 | 4.1 kb | Proximal (<10kb) | 31 | |
| chr7:116,965,153–116,965,353 | 8.5 kb | Proximal (<10kb) | 1 |
Genomic view of the ST7-OT4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.