Transcription factors with Perturb-seq knockdown data for ST7-AS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST7-AS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST7-AS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:116,861,960–116,863,478 | 212.2 kb | Distal (>10kb) Multiome | 893 | |
| chr7:116,952,833–116,954,651 | 121.0 kb | Distal (>10kb) Multiome | 944 | |
| chr7:117,072,242–117,073,083 | 1.6 kb | Proximal (<10kb) | 170 | |
| chr7:117,074,085–117,075,019 | at TSS | At TSS | 146 | |
| chr7:117,076,449–117,077,224 | 1.7 kb | Proximal (<10kb) | 99 | |
| chr7:117,081,945–117,082,156 | 7.2 kb | Proximal (<10kb) | 28 | |
| chr7:117,118,679–117,119,151 | 44.2 kb | Distal (>10kb) Multiome | 153 | |
| chr7:117,322,289–117,325,322 | 249.6 kb | Distal (>10kb) Multiome | 391 |
Genomic view of the ST7-AS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.