SSH3
slingshot protein phosphatase 3 | FLJ10928, FLJ20515

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]

Developmental clusters: GC7
Biological processes 14 terms
actin binding (GO:0003779)actin binding (GO:0003779)actin cytoskeleton organization (GO:0030036)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)negative regulation of actin filament polymerization (GO:0030837)negative regulation of actin filament polymerization (GO:0030837)nucleus (GO:0005634)phosphatase activity (GO:0016791)phosphoprotein phosphatase activity (GO:0004721)phosphoprotein phosphatase activity (GO:0004721)protein binding (GO:0005515)protein serine/threonine phosphatase activity (GO:0004722)protein tyrosine phosphatase activity (GO:0004725)
Expression (TPM)
SSH3 — as a Regulated Gene

TFs regulating SSH3 0 TFs

Transcription factors with Perturb-seq knockdown data for SSH3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SSH3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SSH3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SSH3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr11:67,023,002–67,023,688 280.0 kb Distal (>10kb) Multiome 243
chr11:67,056,596–67,057,312 246.6 kb Distal (>10kb) Multiome 382
chr11:67,071,470–67,071,999 231.7 kb Distal (>10kb) Multiome 302
chr11:67,117,553–67,120,314 184.4 kb Distal (>10kb) Multiome 762
chr11:67,239,493–67,240,241 63.6 kb Distal (>10kb) Multiome 792
chr11:67,265,898–67,267,077 37.0 kb Distal (>10kb) Multiome 471
chr11:67,288,260–67,289,971 14.3 kb Distal (>10kb) Multiome 985
chr11:67,302,488–67,304,170 65 bp At TSS Multiome 661
chr11:67,316,992–67,318,501 14.2 kb Distal (>10kb) Multiome 918
chr11:67,352,967–67,354,228 50.2 kb Distal (>10kb) Multiome 781
chr11:67,372,171–67,373,596 69.6 kb Distal (>10kb) Multiome 497
chr11:67,391,276–67,392,428 88.4 kb Distal (>10kb) Multiome 957
chr11:67,401,038–67,402,351 98.4 kb Distal (>10kb) Multiome 741
chr11:67,420,418–67,421,666 117.8 kb Distal (>10kb) Multiome 648
chr11:67,428,036–67,428,950 124.9 kb Distal (>10kb) Multiome 813
chr11:67,443,182–67,444,063 140.2 kb Distal (>10kb) Multiome 612
chr11:67,464,410–67,465,252 161.3 kb Distal (>10kb) Multiome 710
chr11:67,468,551–67,469,666 165.8 kb Distal (>10kb) Multiome 774
chr11:67,482,830–67,483,745 179.7 kb Distal (>10kb) Multiome 969
chr11:67,504,073–67,506,408 202.8 kb Distal (>10kb) Multiome 769
chr11:67,507,504–67,509,030 204.9 kb Distal (>10kb) Multiome 897
chr11:67,583,474–67,584,777 280.2 kb Distal (>10kb) Multiome 633

Genome Browser

Genomic view of the SSH3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr11:67,013,002 – 67,594,777
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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