The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for SRSF6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRSF6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRSF6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:41,617,502–41,619,268 | 1839.3 kb | Distal (>10kb) Multiome HiCAR | 758 | |
| chr20:43,189,406–43,190,294 | 268.0 kb | Distal (>10kb) Multiome | 136 | |
| chr20:43,449,056–43,449,240 | 8.7 kb | Proximal (<10kb) | 273 | |
| chr20:43,457,127–43,458,915 | 160 bp | At TSS Multiome | 1116 | |
| chr20:43,507,189–43,508,028 | 49.8 kb | Distal (>10kb) Multiome | 658 | |
| chr20:43,508,294–43,509,032 | 51.0 kb | Distal (>10kb) Multiome | 227 | |
| chr20:43,513,723–43,515,130 | 56.4 kb | Distal (>10kb) Multiome | 700 | |
| chr20:43,590,411–43,591,331 | 133.0 kb | Distal (>10kb) Multiome | 897 | |
| chr20:43,657,233–43,658,086 | 199.7 kb | Distal (>10kb) Multiome | 995 | |
| chr20:43,666,536–43,667,856 | 209.1 kb | Distal (>10kb) Multiome | 852 | |
| chr20:43,732,772–43,733,261 | 275.2 kb | Distal (>10kb) Multiome | 21 |
Genomic view of the SRSF6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.