Enables RNA binding activity. Involved in mRNA 5'-splice site recognition and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SRSF12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRSF12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRSF12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:88,963,119–88,964,135 | 154.3 kb | Distal (>10kb) Multiome | 826 | |
| chr6:88,972,890–88,973,787 | 144.7 kb | Distal (>10kb) Multiome | 345 | |
| chr6:89,079,845–89,082,207 | 37.4 kb | Distal (>10kb) Multiome | 1155 | |
| chr6:89,117,325–89,118,595 | 4 bp | At TSS Multiome | 482 | |
| chr6:89,145,740–89,146,828 | 28.3 kb | Distal (>10kb) Multiome | 853 | |
| chr6:89,242,677–89,243,345 | 125.1 kb | Distal (>10kb) Multiome | 160 | |
| chr6:89,311,590–89,312,158 | 194.0 kb | Distal (>10kb) Multiome | 214 | |
| chr6:89,352,138–89,353,410 | 234.8 kb | Distal (>10kb) Multiome | 882 | |
| chr6:89,411,134–89,412,806 | 294.0 kb | Distal (>10kb) Multiome | 540 |
Genomic view of the SRSF12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.