Enables mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Involved in primary miRNA processing. Located in nucleoplasm. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SRRT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRRT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRRT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,585,161–100,587,241 | 288.7 kb | Distal (>10kb) Multiome | 966 | |
| chr7:100,611,685–100,612,981 | 262.9 kb | Distal (>10kb) Multiome | 767 | |
| chr7:100,626,427–100,627,057 | 248.3 kb | Distal (>10kb) Multiome | 415 | |
| chr7:100,656,111–100,656,626 | 218.7 kb | Distal (>10kb) Multiome | 653 | |
| chr7:100,673,043–100,674,892 | 201.6 kb | Distal (>10kb) Multiome | 934 | |
| chr7:100,674,996–100,676,406 | 199.2 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,691,570–100,692,163 | 183.2 kb | Distal (>10kb) Multiome | 364 | |
| chr7:100,693,475–100,694,667 | 180.8 kb | Distal (>10kb) Multiome | 607 | |
| chr7:100,705,140–100,706,426 | 169.2 kb | Distal (>10kb) Multiome | 962 | |
| chr7:100,827,001–100,828,324 | 47.4 kb | Distal (>10kb) Multiome | 794 | |
| chr7:100,835,906–100,837,766 | 38.3 kb | Distal (>10kb) Multiome | 766 | |
| chr7:100,852,057–100,853,190 | 22.6 kb | Distal (>10kb) Multiome | 805 | |
| chr7:100,866,996–100,867,410 | 7.7 kb | Proximal (<10kb) | 641 | |
| chr7:100,867,493–100,867,748 | 7.4 kb | Proximal (<10kb) | 402 | |
| chr7:100,874,652–100,875,664 | 81 bp | At TSS Multiome | 1020 | |
| chr7:100,888,882–100,891,520 | 14.7 kb | Distal (>10kb) Multiome | 1077 | |
| chr7:100,894,188–100,896,392 | 20.9 kb | Distal (>10kb) Multiome | 609 | |
| chr7:100,896,481–100,897,567 | 22.0 kb | Distal (>10kb) Multiome | 538 | |
| chr7:101,085,076–101,085,958 | 210.4 kb | Distal (>10kb) Multiome | 732 | |
| chr7:101,153,861–101,155,183 | 279.3 kb | Distal (>10kb) Multiome | 670 | |
| chr7:101,162,599–101,164,796 | 288.0 kb | Distal (>10kb) Multiome | 654 | |
| chr7:101,165,195–101,166,546 | 290.6 kb | Distal (>10kb) Multiome | 980 | |
| chr7:101,173,985–101,174,835 | 299.1 kb | Distal (>10kb) Multiome | 323 |
Genomic view of the SRRT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.