Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including R-loop processing; peptidyl-serine phosphorylation; and regulation of viral genome replication. Located in chromatin; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SRPK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRPK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRPK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:105,350,605–105,351,448 | 38.3 kb | Distal (>10kb) Multiome | 116 | |
| chr7:105,387,785–105,389,508 | 390 bp | At TSS Multiome | 725 | |
| chr7:105,521,330–105,522,854 | 132.8 kb | Distal (>10kb) Multiome | 900 | |
| chr7:105,531,803–105,532,700 | 142.8 kb | Distal (>10kb) Multiome | 946 | |
| chr7:105,580,977–105,581,814 | 192.1 kb | Distal (>10kb) Multiome | 492 | |
| chr7:105,638,494–105,639,567 | 249.9 kb | Distal (>10kb) Multiome | 209 | |
| chr7:105,643,274–105,643,732 | 254.2 kb | Distal (>10kb) Multiome | 211 | |
| chr7:105,651,976–105,652,948 | 263.2 kb | Distal (>10kb) Multiome | 292 | |
| chr7:105,655,354–105,656,152 | 266.3 kb | Distal (>10kb) Multiome | 203 | |
| chr7:105,657,015–105,657,727 | 267.9 kb | Distal (>10kb) Multiome | 205 | |
| chr7:105,664,641–105,665,449 | 275.7 kb | Distal (>10kb) Multiome | 422 | |
| chr7:105,689,008–105,690,124 | 300.0 kb | Distal (>10kb) Multiome | 195 |
Genomic view of the SRPK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.