This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for SRP68. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRP68 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRP68, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:75,778,786–75,780,191 | 292.6 kb | Distal (>10kb) Multiome | 1118 | |
| chr17:75,784,060–75,785,640 | 287.6 kb | Distal (>10kb) Multiome | 1176 | |
| chr17:75,827,420–75,828,293 | 244.7 kb | Distal (>10kb) Multiome | 404 | |
| chr17:75,830,158–75,830,695 | 242.1 kb | Distal (>10kb) Multiome | 190 | |
| chr17:75,832,912–75,833,396 | 239.3 kb | Distal (>10kb) Multiome | 104 | |
| chr17:75,845,103–75,845,662 | 227.1 kb | Distal (>10kb) Multiome | 703 | |
| chr17:75,854,955–75,856,363 | 217.0 kb | Distal (>10kb) Multiome | 1038 | |
| chr17:75,877,486–75,878,900 | 194.5 kb | Distal (>10kb) Multiome | 884 | |
| chr17:75,896,392–75,897,754 | 175.5 kb | Distal (>10kb) Multiome | 831 | |
| chr17:75,904,371–75,905,532 | 167.4 kb | Distal (>10kb) Multiome | 1045 | |
| chr17:75,940,734–75,941,471 | 131.4 kb | Distal (>10kb) Multiome | 982 | |
| chr17:75,978,646–75,980,102 | 93.1 kb | Distal (>10kb) Multiome | 1090 | |
| chr17:75,983,292–75,984,226 | 88.7 kb | Distal (>10kb) Multiome | 236 | |
| chr17:76,014,120–76,014,727 | 58.1 kb | Distal (>10kb) Multiome | 489 | |
| chr17:76,029,331–76,030,158 | 42.8 kb | Distal (>10kb) Multiome | 722 | |
| chr17:76,067,009–76,067,331 | 5.2 kb | Proximal (<10kb) | 11 | |
| chr17:76,072,173–76,072,853 | 79 bp | At TSS Multiome | 893 | |
| chr17:76,074,414–76,075,796 | 2.2 kb | Proximal (<10kb) Multiome | 280 | |
| chr17:76,103,272–76,104,343 | 31.3 kb | Distal (>10kb) Multiome | 798 | |
| chr17:76,121,142–76,122,265 | 49.1 kb | Distal (>10kb) Multiome | 689 | |
| chr17:76,132,004–76,133,216 | 60.2 kb | Distal (>10kb) Multiome | 536 | |
| chr17:76,135,151–76,135,652 | 62.8 kb | Distal (>10kb) Multiome | 104 | |
| chr17:76,141,012–76,141,958 | 68.9 kb | Distal (>10kb) Multiome | 616 | |
| chr17:76,240,278–76,241,169 | 168.2 kb | Distal (>10kb) Multiome | 560 | |
| chr17:76,264,834–76,266,286 | 192.7 kb | Distal (>10kb) Multiome | 868 | |
| chr17:76,353,245–76,354,535 | 281.5 kb | Distal (>10kb) Multiome | 1071 |
Genomic view of the SRP68 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.