Enables several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Contributes to GTPase activity. Involved in granulocyte differentiation and protein targeting to ER. Located in cytosol and nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. Implicated in severe congenital neutropenia 8. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SRP54. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRP54 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRP54, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:34,693,166–34,693,989 | 289.3 kb | Distal (>10kb) Multiome | 463 | |
| chr14:34,713,982–34,715,044 | 268.0 kb | Distal (>10kb) Multiome | 919 | |
| chr14:34,873,262–34,875,515 | 107.5 kb | Distal (>10kb) Multiome | 1146 | |
| chr14:34,981,885–34,983,443 | 26 bp | At TSS Multiome | 1124 | |
| chr14:35,045,870–35,047,118 | 63.6 kb | Distal (>10kb) Multiome | 1047 | |
| chr14:35,121,659–35,123,040 | 139.3 kb | Distal (>10kb) Multiome | 1148 |
Genomic view of the SRP54 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.