Enables protein kinase binding activity. Involved in several processes, including postsynaptic actin cytoskeleton organization; regulation of protein tyrosine kinase activity; and substrate adhesion-dependent cell spreading. Located in actin cytoskeleton and cytoplasm. Is active in glutamatergic synapse. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SRCIN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SRCIN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SRCIN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:38,351,522–38,352,472 | 207.6 kb | Distal (>10kb) Multiome | 809 | |
| chr17:38,414,746–38,415,878 | 144.5 kb | Distal (>10kb) Multiome | 792 | |
| chr17:38,509,961–38,510,926 | 48.9 kb | Distal (>10kb) Multiome | 409 | |
| chr17:38,558,106–38,558,652 | 1.1 kb | Proximal (<10kb) Multiome | 631 | |
| chr17:38,559,205–38,559,900 | 173 bp | At TSS Multiome | 598 | |
| chr17:38,561,667–38,562,245 | 2.2 kb | Proximal (<10kb) | 77 | |
| chr17:38,572,553–38,573,232 | 13.5 kb | Distal (>10kb) Multiome | 231 | |
| chr17:38,578,170–38,578,490 | 5.3 kb | Proximal (<10kb) | 125 | |
| chr17:38,598,546–38,598,954 | 7.0 kb | Proximal (<10kb) | 426 | |
| chr17:38,604,448–38,605,250 | 45.4 kb | Distal (>10kb) Multiome | 375 | |
| chr17:38,605,359–38,606,888 | 47.1 kb | Distal (>10kb) Multiome | 781 | |
| chr17:38,609,172–38,610,061 | 50.2 kb | Distal (>10kb) Multiome | 229 | |
| chr17:38,673,658–38,675,315 | 115.6 kb | Distal (>10kb) Multiome | 847 | |
| chr17:38,701,857–38,703,072 | 142.9 kb | Distal (>10kb) Multiome | 907 | |
| chr17:38,703,568–38,704,668 | 144.5 kb | Distal (>10kb) Multiome | 955 | |
| chr17:38,704,725–38,707,220 | 145.8 kb | Distal (>10kb) Multiome | 784 | |
| chr17:38,718,492–38,719,127 | 159.3 kb | Distal (>10kb) Multiome | 268 | |
| chr17:38,719,228–38,720,635 | 160.8 kb | Distal (>10kb) Multiome | 290 | |
| chr17:38,729,824–38,730,713 | 170.8 kb | Distal (>10kb) Multiome HiCAR | 794 | |
| chr17:38,747,498–38,750,334 | 190.4 kb | Distal (>10kb) Multiome | 914 | |
| chr17:38,751,747–38,753,201 | 193.2 kb | Distal (>10kb) Multiome | 986 | |
| chr17:38,798,912–38,800,293 | 240.4 kb | Distal (>10kb) Multiome | 966 | |
| chr17:38,824,673–38,825,720 | 265.9 kb | Distal (>10kb) Multiome | 978 | |
| chr17:38,853,382–38,854,144 | 294.3 kb | Distal (>10kb) Multiome | 1047 | |
| chr17:38,867,391–38,868,381 | 308.2 kb | Distal (>10kb) Multiome | 640 | |
| chr17:38,869,253–38,871,194 | 310.3 kb | Distal (>10kb) Multiome | 1074 |
Genomic view of the SRCIN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.