Transcription factors with Perturb-seq knockdown data for SPINT1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPINT1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPINT1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:40,593,777–40,594,776 | 250.2 kb | Distal (>10kb) Multiome | 899 | |
| chr15:40,694,639–40,695,262 | 149.2 kb | Distal (>10kb) Multiome | 831 | |
| chr15:40,754,834–40,755,729 | 88.9 kb | Distal (>10kb) Multiome | 816 | |
| chr15:40,806,990–40,807,956 | 36.7 kb | Distal (>10kb) Multiome | 782 | |
| chr15:40,843,756–40,844,502 | 149 bp | At TSS Multiome | 364 | |
| chr15:40,873,588–40,874,396 | 29.7 kb | Distal (>10kb) Multiome | 556 | |
| chr15:40,893,927–40,894,547 | 50.0 kb | Distal (>10kb) Multiome | 741 | |
| chr15:40,906,419–40,906,902 | 62.3 kb | Distal (>10kb) Multiome | 630 | |
| chr15:40,941,651–40,942,174 | 97.6 kb | Distal (>10kb) Multiome | 643 | |
| chr15:40,952,899–40,953,683 | 109.0 kb | Distal (>10kb) Multiome | 618 | |
| chr15:41,115,645–41,116,753 | 272.1 kb | Distal (>10kb) Multiome | 909 |
Genomic view of the SPINT1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.