Enables signaling receptor complex adaptor activity and ubiquitin-specific protease binding activity. Involved in several processes, including protein deubiquitination; regulation of necroptotic process; and regulation of tumor necrosis factor-mediated signaling pathway. Located in cytoplasm; fibrillar center; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SPATA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPATA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPATA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:49,713,090–49,714,241 | 201.6 kb | Distal (>10kb) Multiome | 875 | |
| chr20:49,812,498–49,813,345 | 102.7 kb | Distal (>10kb) Multiome | 943 | |
| chr20:49,915,234–49,916,043 | 107 bp | At TSS Multiome | 965 | |
| chr20:49,936,000–49,936,835 | 20.8 kb | Distal (>10kb) Multiome | 878 | |
| chr20:49,979,039–49,979,667 | 63.8 kb | Distal (>10kb) Multiome | 832 | |
| chr20:49,982,091–49,984,748 | 67.3 kb | Distal (>10kb) Multiome | 1116 | |
| chr20:50,112,672–50,113,319 | 197.6 kb | Distal (>10kb) Multiome | 839 | |
| chr20:50,153,404–50,154,338 | 238.3 kb | Distal (>10kb) Multiome | 1028 | |
| chr20:50,165,812–50,166,377 | 250.6 kb | Distal (>10kb) Multiome | 1037 | |
| chr20:50,171,676–50,172,948 | 256.9 kb | Distal (>10kb) Multiome | 821 | |
| chr20:50,189,686–50,192,514 | 275.0 kb | Distal (>10kb) Multiome | 1125 |
Genomic view of the SPATA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.