Enables microtubule binding activity. Involved in axoneme assembly. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SPACA9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SPACA9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SPACA9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:132,582,095–132,582,589 | 296.7 kb | Distal (>10kb) Multiome | 938 | |
| chr9:132,794,730–132,795,358 | 83.9 kb | Distal (>10kb) Multiome | 159 | |
| chr9:132,877,859–132,878,978 | 475 bp | At TSS Multiome | 676 | |
| chr9:132,944,084–132,945,377 | 65.9 kb | Distal (>10kb) Multiome | 983 | |
| chr9:133,030,039–133,031,100 | 151.8 kb | Distal (>10kb) Multiome | 998 | |
| chr9:133,059,688–133,060,833 | 181.6 kb | Distal (>10kb) Multiome | 222 | |
| chr9:133,120,589–133,121,652 | 242.4 kb | Distal (>10kb) Multiome | 599 | |
| chr9:133,144,161–133,144,920 | 265.7 kb | Distal (>10kb) Multiome | 776 | |
| chr9:133,147,412–133,149,938 | 270.5 kb | Distal (>10kb) Multiome | 979 | |
| chr9:133,163,575–133,164,128 | 285.0 kb | Distal (>10kb) Multiome | 308 |
Genomic view of the SPACA9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.