The protein encoded by this gene is a nuclear zinc finger protein that is involved in development of the cochlea. Defects in this gene have also been linked to intellectual disability. [provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for SOBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SOBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SOBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:107,458,801–107,460,297 | 30.5 kb | Distal (>10kb) Multiome | 965 | |
| chr6:107,488,810–107,490,838 | 62 bp | At TSS Multiome | 600 | |
| chr6:107,490,991–107,491,560 | 886 bp | At TSS | 373 | |
| chr6:107,634,247–107,635,413 | 144.8 kb | Distal (>10kb) Multiome HiCAR | 133 | |
| chr6:107,675,165–107,675,837 | 185.4 kb | Distal (>10kb) Multiome | 556 |
Genomic view of the SOBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.