SNX33
sorting nexin 33 | MGC32065, SH3PXD3C, SNX30, SH3PX3

The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Biological processes 37 terms
cleavage furrow formation (GO:0036089)cleavage furrow formation (GO:0036089)cleavage furrow formation (GO:0036089)cytoplasmic vesicle (GO:0031410)cytoplasmic vesicle (GO:0031410)cytoplasmic vesicle (GO:0031410)cytoplasmic vesicle membrane (GO:0030659)cytosol (GO:0005829)cytosol (GO:0005829)endocytosis (GO:0006897)endocytosis (GO:0006897)endocytosis (GO:0006897)endosomal transport (GO:0016197)endosomal transport (GO:0016197)endosomal transport (GO:0016197)endosome organization (GO:0007032)identical protein binding (GO:0042802)intracellular protein transport (GO:0006886)macropinocytosis (GO:0044351)membrane (GO:0016020)membrane (GO:0016020)mitotic cell cycle (GO:0000278)mitotic cytokinesis (GO:0000281)mitotic cytokinesis (GO:0000281)negative regulation of endocytosis (GO:0045806)negative regulation of protein localization to cell surface (GO:2000009)phosphatidylinositol binding (GO:0035091)phosphatidylinositol binding (GO:0035091)plasma membrane (GO:0005886)plasma membrane tubulation (GO:0097320)plasma membrane tubulation (GO:0097320)positive regulation of catabolic process (GO:0009896)positive regulation of membrane protein ectodomain proteolysis (GO:0051044)positive regulation of protein localization to cell surface (GO:2000010)protein binding (GO:0005515)protein import (GO:0017038)protein transport (GO:0015031)
Expression (TPM)
SNX33 — as a Regulated Gene

TFs regulating SNX33 0 TFs

Transcription factors with Perturb-seq knockdown data for SNX33. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNX33 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SNX33

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNX33, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr15:75,367,625–75,369,002 279.7 kb Distal (>10kb) Multiome HiCAR 1121
chr15:75,450,273–75,456,388 195.9 kb Distal (>10kb) Multiome 1174
chr15:75,579,138–75,580,015 68.5 kb Distal (>10kb) Multiome 683
chr15:75,624,816–75,626,356 22.1 kb Distal (>10kb) Multiome 987
chr15:75,639,562–75,640,798 7.6 kb Proximal (<10kb) Multiome 999
chr15:75,647,017–75,648,674 27 bp At TSS Multiome 795
chr15:75,712,716–75,713,248 65.0 kb Distal (>10kb) Multiome 318
chr15:75,738,177–75,739,332 90.8 kb Distal (>10kb) Multiome 611
chr15:75,758,383–75,758,865 110.7 kb Distal (>10kb) Multiome 550
chr15:75,823,901–75,824,543 176.3 kb Distal (>10kb) Multiome 98
chr15:75,842,738–75,844,503 195.4 kb Distal (>10kb) Multiome 842
chr15:75,903,363–75,904,635 256.0 kb Distal (>10kb) Multiome 958

Genome Browser

Genomic view of the SNX33 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr15:75,357,625 – 75,914,635
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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