This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for SNX10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNX10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNX10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:26,151,798–26,154,281 | 139.7 kb | Distal (>10kb) Multiome | 635 | |
| chr7:26,199,573–26,202,470 | 90.9 kb | Distal (>10kb) Multiome | 1167 | |
| chr7:26,291,673–26,292,388 | 17 bp | At TSS Multiome | 647 | |
| chr7:26,375,964–26,377,507 | 85.2 kb | Distal (>10kb) Multiome | 698 | |
| chr7:26,397,280–26,399,477 | 106.7 kb | Distal (>10kb) Multiome | 678 |
Genomic view of the SNX10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.