This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for SNW1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNW1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNW1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:77,498,012–77,499,509 | 262.3 kb | Distal (>10kb) Multiome | 599 | |
| chr14:77,615,862–77,617,380 | 144.3 kb | Distal (>10kb) Multiome | 892 | |
| chr14:77,654,873–77,655,664 | 105.9 kb | Distal (>10kb) Multiome | 287 | |
| chr14:77,707,585–77,708,371 | 53.1 kb | Distal (>10kb) Multiome | 744 | |
| chr14:77,760,384–77,761,929 | 73 bp | At TSS Multiome | 755 | |
| chr14:77,799,937–77,800,798 | 39.1 kb | Distal (>10kb) Multiome | 865 | |
| chr14:77,965,921–77,966,514 | 205.1 kb | Distal (>10kb) Multiome | 258 | |
| chr14:77,980,545–77,981,614 | 219.9 kb | Distal (>10kb) Multiome | 329 | |
| chr14:78,029,563–78,030,313 | 268.7 kb | Distal (>10kb) Multiome | 227 |
Genomic view of the SNW1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.