The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins (snRNP) that form part of the U12-type spliceosome. Alternative splicing results in multiple transcript variants encoding two distinct isoforms and representing a non-protein coding variant. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for SNRNP35. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNRNP35 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNRNP35, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:123,232,511–123,233,923 | 225.0 kb | Distal (>10kb) Multiome | 1073 | |
| chr12:123,269,375–123,269,864 | 188.4 kb | Distal (>10kb) Multiome | 217 | |
| chr12:123,270,951–123,272,226 | 186.9 kb | Distal (>10kb) Multiome | 488 | |
| chr12:123,363,804–123,365,980 | 93.0 kb | Distal (>10kb) Multiome | 1015 | |
| chr12:123,383,367–123,384,963 | 74.2 kb | Distal (>10kb) Multiome | 836 | |
| chr12:123,388,500–123,389,409 | 69.3 kb | Distal (>10kb) Multiome | 446 | |
| chr12:123,436,072–123,436,895 | 21.5 kb | Distal (>10kb) Multiome | 742 | |
| chr12:123,458,045–123,458,697 | 268 bp | At TSS Multiome | 925 | |
| chr12:123,533,444–123,534,540 | 75.9 kb | Distal (>10kb) Multiome | 718 | |
| chr12:123,583,890–123,585,003 | 126.3 kb | Distal (>10kb) Multiome | 928 | |
| chr12:123,601,617–123,602,401 | 143.9 kb | Distal (>10kb) Multiome | 1076 | |
| chr12:123,633,273–123,633,970 | 175.6 kb | Distal (>10kb) Multiome | 886 | |
| chr12:123,670,899–123,671,414 | 213.0 kb | Distal (>10kb) Multiome | 469 | |
| chr12:123,711,684–123,712,955 | 254.1 kb | Distal (>10kb) Multiome | 771 | |
| chr12:123,719,176–123,720,140 | 261.5 kb | Distal (>10kb) Multiome | 303 |
Genomic view of the SNRNP35 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.