Small nucleolar RNAs (snoRNAs) of the C/D class, such as SNORD87, are involved in 2-prime-methylation of preribosomal RNA precursors (Gogolevskaya et al., 2002 [PubMed 12119114]).[supplied by OMIM, Aug 2008]
Transcription factors with Perturb-seq knockdown data for SNORD87. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNORD87 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNORD87, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:66,919,451–66,919,596 | 3.0 kb | Proximal (<10kb) | 118 | |
| chr8:66,920,080–66,921,072 | 1.5 kb | Proximal (<10kb) | 204 | |
| chr8:66,924,535–66,926,136 | 2.0 kb | Proximal (<10kb) | 998 | |
| chr8:66,926,425–66,926,599 | 3.9 kb | Proximal (<10kb) | 53 |
Genomic view of the SNORD87 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.