SNORD50B is a C/D box-type small nucleolar RNA (snoRNA) that is predicted to function as a guide RNA in 2-prime O-methylation of 28S ribosomal RNA (Tanaka et al., 2000 [PubMed 10792466]).[supplied by OMIM, Feb 2010]
Transcription factors with Perturb-seq knockdown data for SNORD50B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNORD50B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNORD50B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:85,667,231–85,667,679 | 10.0 kb | Proximal (<10kb) | 12 | |
| chr6:85,667,935–85,668,441 | 9.2 kb | Proximal (<10kb) | 6 | |
| chr6:85,669,340–85,674,412 | 3.2 kb | Proximal (<10kb) | 586 | |
| chr6:85,674,652–85,675,780 | 1.9 kb | Proximal (<10kb) | 256 | |
| chr6:85,677,372–85,679,519 | at TSS | At TSS | 1177 |
Genomic view of the SNORD50B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.