Transcription factors with Perturb-seq knockdown data for SNHG31. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNHG31 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNHG31, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:213,283,867–213,285,119 | 1525.8 kb | Distal (>10kb) Multiome HiCAR | 863 | |
| chr2:214,593,496–214,594,272 | 216.3 kb | Distal (>10kb) Multiome | 211 | |
| chr2:214,630,073–214,631,010 | 179.7 kb | Distal (>10kb) Multiome | 172 | |
| chr2:214,802,982–214,803,516 | 6.7 kb | Proximal (<10kb) | 2 | |
| chr2:214,808,156–214,811,140 | 245 bp | At TSS Multiome | 969 | |
| chr2:214,814,232–214,814,439 | 4.0 kb | Proximal (<10kb) | 13 | |
| chr2:215,089,705–215,091,041 | 280.0 kb | Distal (>10kb) Multiome | 134 |
Genomic view of the SNHG31 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.