Transcription factors with Perturb-seq knockdown data for SNHG30. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNHG30 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNHG30, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:35,312,777–35,313,483 | 255.1 kb | Distal (>10kb) Multiome | 263 | |
| chr17:35,448,264–35,448,971 | 119.5 kb | Distal (>10kb) Multiome | 350 | |
| chr17:35,460,343–35,460,836 | 107.4 kb | Distal (>10kb) Multiome | 174 | |
| chr17:35,567,580–35,568,368 | 129 bp | At TSS Multiome | 673 | |
| chr17:35,578,257–35,578,977 | 10.5 kb | Distal (>10kb) Multiome | 860 | |
| chr17:35,586,924–35,588,023 | 19.3 kb | Distal (>10kb) Multiome | 932 | |
| chr17:35,731,320–35,732,101 | 163.6 kb | Distal (>10kb) Multiome | 406 | |
| chr17:35,763,993–35,764,924 | 196.3 kb | Distal (>10kb) Multiome | 888 | |
| chr17:35,795,171–35,795,832 | 227.4 kb | Distal (>10kb) Multiome | 290 | |
| chr17:35,808,939–35,810,190 | 241.3 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the SNHG30 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.