Transcription factors with Perturb-seq knockdown data for SNHG21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNHG21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNHG21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:82,571,710–82,572,201 | 178.7 kb | Distal (>10kb) Multiome | 194 | |
| chr15:82,647,462–82,648,736 | 102.3 kb | Distal (>10kb) Multiome | 511 | |
| chr15:82,679,753–82,681,281 | 70.1 kb | Distal (>10kb) Multiome | 495 | |
| chr15:82,708,766–82,710,416 | 40.9 kb | Distal (>10kb) Multiome | 725 | |
| chr15:82,750,200–82,750,777 | 24 bp | At TSS Multiome | 790 | |
| chr15:82,809,212–82,810,601 | 59.1 kb | Distal (>10kb) Multiome | 808 | |
| chr15:82,849,476–82,850,366 | 99.3 kb | Distal (>10kb) Multiome | 450 | |
| chr15:82,952,161–82,953,316 | 202.1 kb | Distal (>10kb) Multiome | 430 | |
| chr15:82,985,830–82,986,497 | 235.6 kb | Distal (>10kb) Multiome | 853 | |
| chr15:83,010,925–83,012,341 | 261.1 kb | Distal (>10kb) Multiome | 964 |
Genomic view of the SNHG21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.