This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits other regulatory factors to activate snRNA gene transcription. The encoded protein may play a role in stabilizing this complex. A pseudogene of this gene has been identified on chromosome 6. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for SNAPC5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNAPC5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNAPC5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:66,252,061–66,253,967 | 245.2 kb | Distal (>10kb) Multiome | 412 | |
| chr15:66,293,215–66,294,349 | 204.1 kb | Distal (>10kb) Multiome | 772 | |
| chr15:66,356,371–66,357,196 | 141.0 kb | Distal (>10kb) Multiome | 889 | |
| chr15:66,386,387–66,387,653 | 110.9 kb | Distal (>10kb) Multiome HiCAR | 899 | |
| chr15:66,472,216–66,473,164 | 25.2 kb | Distal (>10kb) Multiome | 208 | |
| chr15:66,497,104–66,498,247 | 44 bp | At TSS Multiome | 1044 | |
| chr15:66,504,543–66,505,655 | 7.3 kb | Proximal (<10kb) Multiome | 940 | |
| chr15:66,567,056–66,567,492 | 69.5 kb | Distal (>10kb) Multiome | 294 | |
| chr15:66,592,463–66,593,143 | 95.0 kb | Distal (>10kb) Multiome | 154 | |
| chr15:66,621,672–66,622,446 | 124.5 kb | Distal (>10kb) Multiome | 271 | |
| chr15:66,630,856–66,631,340 | 133.4 kb | Distal (>10kb) Multiome | 284 | |
| chr15:66,670,796–66,671,740 | 173.5 kb | Distal (>10kb) Multiome | 241 | |
| chr15:66,673,331–66,673,903 | 176.0 kb | Distal (>10kb) Multiome | 192 | |
| chr15:66,679,362–66,680,264 | 182.1 kb | Distal (>10kb) Multiome | 541 | |
| chr15:66,691,568–66,692,527 | 194.4 kb | Distal (>10kb) Multiome | 33 | |
| chr15:66,698,421–66,699,404 | 201.4 kb | Distal (>10kb) Multiome | 321 | |
| chr15:66,700,619–66,702,650 | 203.4 kb | Distal (>10kb) Multiome | 844 | |
| chr15:66,773,918–66,774,633 | 276.7 kb | Distal (>10kb) Multiome | 524 |
Genomic view of the SNAPC5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.