This gene encodes a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for SNAPC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNAPC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNAPC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:7,629,285–7,629,891 | 290.7 kb | Distal (>10kb) Multiome | 650 | |
| chr19:7,636,753–7,637,571 | 283.3 kb | Distal (>10kb) Multiome | 689 | |
| chr19:7,680,480–7,681,546 | 239.6 kb | Distal (>10kb) Multiome | 679 | |
| chr19:7,829,238–7,830,666 | 90.4 kb | Distal (>10kb) Multiome | 621 | |
| chr19:7,853,168–7,853,781 | 66.9 kb | Distal (>10kb) Multiome | 747 | |
| chr19:7,861,607–7,864,383 | 57.6 kb | Distal (>10kb) Multiome | 348 | |
| chr19:7,868,454–7,870,252 | 50.9 kb | Distal (>10kb) Multiome | 721 | |
| chr19:7,871,072–7,872,772 | 48.2 kb | Distal (>10kb) Multiome | 487 | |
| chr19:7,873,962–7,875,061 | 45.7 kb | Distal (>10kb) Multiome | 416 | |
| chr19:7,888,334–7,888,798 | 31.9 kb | Distal (>10kb) Multiome | 509 | |
| chr19:7,902,730–7,904,931 | 16.6 kb | Distal (>10kb) Multiome | 1000 | |
| chr19:7,916,417–7,916,984 | 3.4 kb | Proximal (<10kb) | 414 | |
| chr19:7,917,358–7,918,182 | 2.4 kb | Proximal (<10kb) Multiome | 316 | |
| chr19:7,919,934–7,921,640 | 307 bp | At TSS Multiome | 802 | |
| chr19:7,924,612–7,926,698 | 4.9 kb | Proximal (<10kb) Multiome | 766 | |
| chr19:7,943,338–7,944,472 | 23.5 kb | Distal (>10kb) Multiome | 974 | |
| chr19:8,001,954–8,002,874 | 82.2 kb | Distal (>10kb) Multiome | 475 | |
| chr19:8,005,202–8,006,197 | 85.4 kb | Distal (>10kb) Multiome | 729 | |
| chr19:8,028,908–8,029,518 | 109.0 kb | Distal (>10kb) Multiome | 122 | |
| chr19:8,050,174–8,051,154 | 130.4 kb | Distal (>10kb) Multiome | 467 | |
| chr19:8,148,316–8,149,986 | 229.2 kb | Distal (>10kb) Multiome | 381 | |
| chr19:8,203,277–8,204,384 | 283.6 kb | Distal (>10kb) Multiome | 150 | |
| chr19:8,208,086–8,210,178 | 288.9 kb | Distal (>10kb) Multiome | 712 |
Genomic view of the SNAPC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.