Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in synaptic vesicle fusion to presynaptic active zone membrane and synaptic vesicle priming. Predicted to act upstream of or within long-term synaptic potentiation. Located in BLOC-1 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SNAP47. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNAP47 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNAP47, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:227,541,755–227,542,988 | 186.0 kb | Distal (>10kb) Multiome | 600 | |
| chr1:227,563,282–227,564,196 | 164.9 kb | Distal (>10kb) Multiome | 889 | |
| chr1:227,728,086–227,729,232 | 173 bp | At TSS Multiome | 590 | |
| chr1:227,729,684–227,729,882 | 1.1 kb | Proximal (<10kb) | 152 | |
| chr1:227,730,363–227,730,812 | 2.0 kb | Proximal (<10kb) Multiome | 276 | |
| chr1:227,734,745–227,735,925 | 6.7 kb | Proximal (<10kb) Multiome | 1052 | |
| chr1:227,787,209–227,789,037 | 59.6 kb | Distal (>10kb) Multiome | 579 | |
| chr1:227,946,348–227,948,809 | 218.1 kb | Distal (>10kb) Multiome HiCAR | 645 | |
| chr1:228,004,351–228,004,883 | 275.9 kb | Distal (>10kb) Multiome | 154 |
Genomic view of the SNAP47 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.