Predicted to enable histone deacetylase binding activity. Involved in heart development. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMYD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMYD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMYD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:1,562,314–1,563,047 | 267.1 kb | Distal (>10kb) Multiome | 685 | |
| chr17:1,589,843–1,590,457 | 239.8 kb | Distal (>10kb) Multiome | 538 | |
| chr17:1,627,811–1,629,617 | 201.2 kb | Distal (>10kb) Multiome | 753 | |
| chr17:1,642,697–1,644,482 | 186.6 kb | Distal (>10kb) Multiome | 467 | |
| chr17:1,648,163–1,650,244 | 180.8 kb | Distal (>10kb) Multiome | 932 | |
| chr17:1,684,343–1,685,342 | 145.0 kb | Distal (>10kb) Multiome | 728 | |
| chr17:1,710,017–1,710,765 | 119.5 kb | Distal (>10kb) Multiome | 500 | |
| chr17:1,713,886–1,717,908 | 112.4 kb | Distal (>10kb) Multiome | 1042 | |
| chr17:1,724,373–1,725,206 | 105.2 kb | Distal (>10kb) Multiome | 720 | |
| chr17:1,829,368–1,830,287 | 26 bp | At TSS Multiome | 660 | |
| chr17:1,908,573–1,908,999 | 78.8 kb | Distal (>10kb) Multiome | 239 | |
| chr17:1,931,964–1,932,566 | 102.4 kb | Distal (>10kb) Multiome | 198 | |
| chr17:1,960,870–1,961,658 | 131.4 kb | Distal (>10kb) Multiome | 192 | |
| chr17:1,997,556–1,998,757 | 168.2 kb | Distal (>10kb) Multiome | 543 | |
| chr17:2,023,483–2,024,229 | 193.9 kb | Distal (>10kb) Multiome | 281 | |
| chr17:2,024,769–2,026,284 | 195.6 kb | Distal (>10kb) Multiome | 459 | |
| chr17:2,029,741–2,030,885 | 201.0 kb | Distal (>10kb) Multiome | 871 | |
| chr17:2,041,423–2,042,366 | 212.0 kb | Distal (>10kb) Multiome | 834 | |
| chr17:2,048,764–2,051,218 | 219.1 kb | Distal (>10kb) Multiome | 658 | |
| chr17:2,053,643–2,054,179 | 223.9 kb | Distal (>10kb) Multiome | 473 | |
| chr17:2,054,616–2,055,766 | 225.2 kb | Distal (>10kb) Multiome | 544 | |
| chr17:2,058,401–2,059,503 | 228.9 kb | Distal (>10kb) Multiome | 366 |
Genomic view of the SMYD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.