Enables identical protein binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMIM3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMIM3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMIM3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:150,485,401–150,487,150 | 292.0 kb | Distal (>10kb) Multiome | 761 | |
| chr5:150,624,424–150,625,067 | 154.0 kb | Distal (>10kb) Multiome | 250 | |
| chr5:150,656,143–150,657,405 | 122.1 kb | Distal (>10kb) Multiome | 607 | |
| chr5:150,671,571–150,672,919 | 106.4 kb | Distal (>10kb) Multiome | 303 | |
| chr5:150,700,548–150,701,464 | 77.8 kb | Distal (>10kb) Multiome | 858 | |
| chr5:150,758,281–150,759,438 | 19.9 kb | Distal (>10kb) Multiome | 902 | |
| chr5:150,778,240–150,779,492 | 59 bp | At TSS Multiome | 723 | |
| chr5:150,783,348–150,783,999 | 4.9 kb | Proximal (<10kb) Multiome | 435 | |
| chr5:150,801,105–150,801,901 | 22.6 kb | Distal (>10kb) Multiome | 382 | |
| chr5:151,020,249–151,021,200 | 241.8 kb | Distal (>10kb) Multiome | 522 |
Genomic view of the SMIM3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.