Enables GTPase activator activity; protein kinase binding activity; and protein kinase inhibitor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in negative regulation of gene expression; regulation of TOR signaling; and regulation of macroautophagy. Located in Atg1/ULK1 kinase complex; chromatin; and nucleoplasm. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SMCR8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMCR8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMCR8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:16,835,071–16,835,593 | 1479.8 kb | Distal (>10kb) Multiome HiCAR | 72 | |
| chr17:18,035,659–18,036,594 | 279.3 kb | Distal (>10kb) Multiome | 186 | |
| chr17:18,038,656–18,040,279 | 276.0 kb | Distal (>10kb) Multiome | 839 | |
| chr17:18,153,365–18,154,352 | 161.3 kb | Distal (>10kb) Multiome | 244 | |
| chr17:18,157,790–18,158,725 | 157.1 kb | Distal (>10kb) Multiome | 292 | |
| chr17:18,182,585–18,185,065 | 131.8 kb | Distal (>10kb) Multiome | 1051 | |
| chr17:18,224,148–18,226,173 | 90.6 kb | Distal (>10kb) Multiome | 680 | |
| chr17:18,246,777–18,247,912 | 68.0 kb | Distal (>10kb) Multiome | 314 | |
| chr17:18,257,865–18,259,083 | 56.6 kb | Distal (>10kb) Multiome | 684 | |
| chr17:18,260,145–18,261,582 | 54.6 kb | Distal (>10kb) Multiome | 778 | |
| chr17:18,314,513–18,315,715 | 155 bp | At TSS Multiome | 865 | |
| chr17:18,363,090–18,363,830 | 48.3 kb | Distal (>10kb) Multiome | 760 |
Genomic view of the SMCR8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.