Transcription factors with Perturb-seq knockdown data for SLX4IP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLX4IP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLX4IP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:10,217,180–10,219,942 | 216.6 kb | Distal (>10kb) Multiome | 1107 | |
| chr20:10,412,635–10,413,529 | 22.1 kb | Distal (>10kb) Multiome | 215 | |
| chr20:10,433,347–10,435,565 | 71 bp | At TSS Multiome | 1181 | |
| chr20:10,637,187–10,638,013 | 202.4 kb | Distal (>10kb) Multiome | 259 | |
| chr20:10,671,398–10,673,077 | 236.5 kb | Distal (>10kb) Multiome | 949 | |
| chr20:10,673,196–10,675,289 | 238.8 kb | Distal (>10kb) Multiome | 1034 |
Genomic view of the SLX4IP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.