This gene encodes a protein that functions as an assembly component of multiple structure-specific endonucleases. These endonuclease complexes are required for repair of specific types of DNA lesions and critical for cellular responses to replication fork failure. Mutations in this gene were found in patients with Fanconi anemia. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for SLX4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLX4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLX4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:3,400,631–3,401,665 | 210.5 kb | Distal (>10kb) Multiome | 927 | |
| chr16:3,457,535–3,458,643 | 153.7 kb | Distal (>10kb) Multiome | 954 | |
| chr16:3,500,701–3,501,337 | 110.6 kb | Distal (>10kb) Multiome | 953 | |
| chr16:3,610,900–3,612,357 | 43 bp | At TSS Multiome | 733 | |
| chr16:3,654,171–3,654,861 | 42.9 kb | Distal (>10kb) Multiome | 445 | |
| chr16:3,716,849–3,718,043 | 106.0 kb | Distal (>10kb) Multiome | 839 | |
| chr16:3,879,373–3,881,582 | 269.3 kb | Distal (>10kb) Multiome | 727 |
Genomic view of the SLX4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.