Transcription factors with Perturb-seq knockdown data for SLFNL1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLFNL1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLFNL1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:40,783,386–40,784,649 | 230.7 kb | Distal (>10kb) Multiome | 448 | |
| chr1:40,802,183–40,803,007 | 212.1 kb | Distal (>10kb) Multiome | 455 | |
| chr1:40,818,171–40,819,026 | 195.8 kb | Distal (>10kb) Multiome | 236 | |
| chr1:40,861,144–40,862,924 | 152.1 kb | Distal (>10kb) Multiome | 724 | |
| chr1:40,952,369–40,952,943 | 62.0 kb | Distal (>10kb) Multiome | 442 | |
| chr1:40,978,861–40,980,635 | 34.9 kb | Distal (>10kb) Multiome | 809 | |
| chr1:41,021,596–41,022,211 | 7.3 kb | Proximal (<10kb) Multiome | 181 | |
| chr1:41,241,300–41,242,832 | 227.5 kb | Distal (>10kb) Multiome | 773 |
Genomic view of the SLFNL1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.