Enables RNA endonuclease activity. Involved in rRNA catabolic process and tRNA decay. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLFN13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLFN13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLFN13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:35,242,191–35,243,858 | 205.9 kb | Distal (>10kb) Multiome | 590 | |
| chr17:35,312,777–35,313,483 | 135.8 kb | Distal (>10kb) Multiome | 263 | |
| chr17:35,448,264–35,448,971 | 161 bp | At TSS Multiome | 350 | |
| chr17:35,460,343–35,460,836 | 11.9 kb | Distal (>10kb) Multiome | 174 | |
| chr17:35,567,580–35,568,368 | 119.2 kb | Distal (>10kb) Multiome | 673 | |
| chr17:35,578,257–35,578,977 | 129.8 kb | Distal (>10kb) Multiome | 860 | |
| chr17:35,586,924–35,588,023 | 138.6 kb | Distal (>10kb) Multiome | 932 | |
| chr17:35,731,320–35,732,101 | 282.9 kb | Distal (>10kb) Multiome | 406 |
Genomic view of the SLFN13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.