Transcription factors with Perturb-seq knockdown data for SLCO5A1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLCO5A1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLCO5A1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:69,710,813–69,711,725 | 122.8 kb | Distal (>10kb) Multiome | 177 | |
| chr8:69,831,934–69,835,337 | 1.6 kb | Proximal (<10kb) Multiome | 736 | |
| chr8:69,977,364–69,977,835 | 143.4 kb | Distal (>10kb) Multiome | 156 | |
| chr8:69,995,289–69,995,821 | 161.6 kb | Distal (>10kb) Multiome | 42 | |
| chr8:70,034,558–70,035,468 | 200.9 kb | Distal (>10kb) Multiome | 244 | |
| chr8:70,060,654–70,062,013 | 227.4 kb | Distal (>10kb) Multiome | 276 | |
| chr8:70,068,781–70,072,924 | 238.0 kb | Distal (>10kb) Multiome | 400 |
Genomic view of the SLCO5A1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.