Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to act upstream of or within flagellated sperm motility. Predicted to be located in membrane and motile cilium. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC9C1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC9C1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC9C1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:111,998,552–111,999,758 | 295.1 kb | Distal (>10kb) Multiome | 325 | |
| chr3:112,048,832–112,049,452 | 245.1 kb | Distal (>10kb) Multiome | 163 | |
| chr3:112,085,739–112,087,192 | 207.8 kb | Distal (>10kb) Multiome | 690 | |
| chr3:112,126,419–112,126,878 | 167.5 kb | Distal (>10kb) Multiome | 150 | |
| chr3:112,136,789–112,137,394 | 157.1 kb | Distal (>10kb) Multiome | 233 | |
| chr3:112,293,399–112,294,560 | 361 bp | At TSS Multiome | 304 | |
| chr3:112,302,106–112,304,027 | 9.2 kb | Proximal (<10kb) Multiome | 204 | |
| chr3:112,321,650–112,322,563 | 27.9 kb | Distal (>10kb) Multiome | 210 | |
| chr3:112,332,830–112,333,873 | 39.0 kb | Distal (>10kb) Multiome | 281 | |
| chr3:112,390,974–112,391,552 | 97.1 kb | Distal (>10kb) Multiome | 215 | |
| chr3:112,399,211–112,401,142 | 106.3 kb | Distal (>10kb) Multiome | 175 | |
| chr3:112,560,905–112,563,207 | 267.9 kb | Distal (>10kb) Multiome HiCAR | 967 |
Genomic view of the SLC9C1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.