Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SLC9B2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC9B2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC9B2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:102,826,418–102,828,875 | 248.7 kb | Distal (>10kb) Multiome | 1216 | |
| chr4:102,868,279–102,869,865 | 207.7 kb | Distal (>10kb) Multiome | 1045 | |
| chr4:103,018,881–103,020,188 | 57.1 kb | Distal (>10kb) Multiome | 882 | |
| chr4:103,075,865–103,077,254 | 263 bp | At TSS Multiome | 845 | |
| chr4:103,197,655–103,198,939 | 121.6 kb | Distal (>10kb) Multiome | 812 |
Genomic view of the SLC9B2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.