The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
Transcription factors with Perturb-seq knockdown data for SLC7A7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC7A7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC7A7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:22,815,392–22,815,755 | at TSS | At TSS | 211 | |
| chr14:22,819,584–22,819,976 | 4.1 kb | Proximal (<10kb) | 264 | |
| chr14:22,821,826–22,823,530 | 6.4 kb | Proximal (<10kb) | 649 | |
| chr14:22,829,704–22,830,328 | 10.0 kb | Proximal (<10kb) | 871 | |
| chr14:22,836,107–22,837,017 | 6.3 kb | Proximal (<10kb) | 320 | |
| chr14:22,837,269–22,838,446 | 7.4 kb | Proximal (<10kb) | 512 |
Genomic view of the SLC7A7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.