SLC7A10
solute carrier family 7 member 10 | asc-1

SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several other neutral amino acids (Nakauchi et al., 2000 [PubMed 10863037]).[supplied by OMIM, Mar 2008]

Biological processes 26 terms
D-alanine transmembrane transport (GO:0042941)D-serine transmembrane transport (GO:0042942)L-alpha-amino acid transmembrane transport (GO:1902475)L-amino acid transmembrane transporter activity (GO:0015179)L-amino acid transmembrane transporter activity (GO:0015179)L-serine transmembrane transporter activity (GO:0015194)L-serine transport (GO:0015825)amino acid import across plasma membrane (GO:0089718)amino acid transport (GO:0006865)glycine transport (GO:0015816)membrane (GO:0016020)membrane (GO:0016020)negative regulation of brown fat cell differentiation (GO:1903444)neutral L-amino acid transmembrane transporter activity (GO:0015175)neutral L-amino acid transmembrane transporter activity (GO:0015175)neutral L-amino acid transmembrane transporter activity (GO:0015175)neutral amino acid transport (GO:0015804)neutral amino acid transport (GO:0015804)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of synaptic transmission, glycinergic (GO:0060094)protein binding (GO:0005515)transmembrane transport (GO:0055085)transmembrane transporter activity (GO:0022857)
Expression (TPM)
SLC7A10 — as a Regulated Gene

TFs regulating SLC7A10 0 TFs

Transcription factors with Perturb-seq knockdown data for SLC7A10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC7A10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SLC7A10

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC7A10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:32,971,721–32,972,560 253.7 kb Distal (>10kb) Multiome 796
chr19:33,022,514–33,023,071 203.1 kb Distal (>10kb) Multiome 102
chr19:33,032,077–33,032,955 193.4 kb Distal (>10kb) Multiome 217
chr19:33,064,252–33,065,504 161.0 kb Distal (>10kb) Multiome 603
chr19:33,080,776–33,081,465 144.8 kb Distal (>10kb) Multiome 838
chr19:33,124,582–33,125,060 101.0 kb Distal (>10kb) Multiome 321
chr19:33,176,278–33,177,966 48.7 kb Distal (>10kb) Multiome 1077
chr19:33,193,912–33,194,503 31.6 kb Distal (>10kb) Multiome 256
chr19:33,225,334–33,226,211 150 bp At TSS Multiome 146
chr19:33,226,520–33,227,396 1.2 kb Proximal (<10kb) Multiome 219
chr19:33,235,322–33,235,543 9.5 kb Proximal (<10kb) 299
chr19:33,301,181–33,303,965 76.8 kb Distal (>10kb) Multiome 945
chr19:33,373,183–33,374,325 147.8 kb Distal (>10kb) Multiome HiCAR 871
chr19:33,406,730–33,407,310 181.1 kb Distal (>10kb) Multiome HiCAR 393
chr19:33,520,926–33,522,397 296.0 kb Distal (>10kb) Multiome 747
chr19:33,777,882–33,778,531 552.3 kb Distal (>10kb) Multiome HiCAR 668

Genome Browser

Genomic view of the SLC7A10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:32,961,721 – 33,788,531
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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