Enables L-arginine transmembrane transporter activity; L-histidine transmembrane transporter activity; and L-lysine transmembrane transporter activity. Involved in L-amino acid transport and intracellular amino acid homeostasis. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC66A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC66A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC66A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:19,209,669–19,210,758 | 102.0 kb | Distal (>10kb) Multiome | 990 | |
| chr1:19,251,426–19,252,084 | 60.7 kb | Distal (>10kb) Multiome | 930 | |
| chr1:19,311,493–19,312,976 | 112 bp | At TSS Multiome | 868 | |
| chr1:19,338,257–19,338,718 | 26.2 kb | Distal (>10kb) Multiome | 426 | |
| chr1:19,484,474–19,486,386 | 173.4 kb | Distal (>10kb) Multiome | 809 | |
| chr1:19,596,392–19,597,600 | 284.7 kb | Distal (>10kb) Multiome | 888 | |
| chr1:19,640,074–19,641,053 | 328.2 kb | Distal (>10kb) Multiome HiCAR | 418 | |
| chr1:19,643,702–19,645,210 | 331.9 kb | Distal (>10kb) Multiome HiCAR | 427 | |
| chr1:19,653,578–19,654,269 | 341.6 kb | Distal (>10kb) Multiome HiCAR | 321 | |
| chr1:19,659,723–19,660,209 | 347.7 kb | Distal (>10kb) Multiome HiCAR | 316 |
Genomic view of the SLC66A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.