This gene encodes a member of the L-amino acid transporter-3 or SLC43 family of transporters. The encoded protein mediates sodium-, chloride-, and pH-independent transport of L-isomers of neutral amino acids, including leucine, phenylalanine, valine and methionine. This protein may contribute to the transfer of amino acids across the placental membrane to the fetus. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for SLC43A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC43A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC43A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:1,399,339–1,400,718 | 228.6 kb | Distal (>10kb) Multiome | 879 | |
| chr17:1,455,335–1,456,916 | 172.5 kb | Distal (>10kb) Multiome | 879 | |
| chr17:1,484,963–1,486,119 | 143.6 kb | Distal (>10kb) Multiome | 562 | |
| chr17:1,487,906–1,488,733 | 140.6 kb | Distal (>10kb) Multiome | 597 | |
| chr17:1,490,717–1,492,156 | 137.5 kb | Distal (>10kb) Multiome | 675 | |
| chr17:1,515,722–1,517,330 | 112.0 kb | Distal (>10kb) Multiome | 796 | |
| chr17:1,562,314–1,563,047 | 66.0 kb | Distal (>10kb) Multiome | 685 | |
| chr17:1,627,811–1,629,617 | 101 bp | At TSS Multiome | 753 | |
| chr17:1,642,697–1,644,482 | 14.5 kb | Distal (>10kb) Multiome | 467 | |
| chr17:1,648,163–1,650,244 | 20.3 kb | Distal (>10kb) Multiome | 932 | |
| chr17:1,684,343–1,685,342 | 56.1 kb | Distal (>10kb) Multiome | 728 | |
| chr17:1,710,017–1,710,765 | 81.6 kb | Distal (>10kb) Multiome | 500 | |
| chr17:1,713,886–1,717,908 | 88.7 kb | Distal (>10kb) Multiome | 1042 | |
| chr17:1,724,373–1,725,206 | 95.9 kb | Distal (>10kb) Multiome | 720 | |
| chr17:1,829,368–1,830,287 | 201.1 kb | Distal (>10kb) Multiome | 660 | |
| chr17:1,908,573–1,908,999 | 279.8 kb | Distal (>10kb) Multiome | 239 |
Genomic view of the SLC43A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.