Enables magnesium:sodium antiporter activity. Involved in mitochondrial magnesium ion transmembrane transport. Located in mitochondrial inner membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC41A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC41A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC41A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:125,915,411–125,917,348 | 167.8 kb | Distal (>10kb) Multiome | 435 | |
| chr3:125,990,235–125,990,695 | 93.6 kb | Distal (>10kb) Multiome | 404 | |
| chr3:126,083,496–126,084,518 | 53 bp | At TSS Multiome | 654 | |
| chr3:126,179,682–126,181,400 | 95.9 kb | Distal (>10kb) Multiome | 438 | |
| chr3:126,212,639–126,213,718 | 129.1 kb | Distal (>10kb) Multiome | 394 | |
| chr3:126,267,216–126,267,888 | 183.5 kb | Distal (>10kb) Multiome | 507 | |
| chr3:126,287,314–126,288,133 | 203.6 kb | Distal (>10kb) Multiome | 237 | |
| chr3:126,355,690–126,356,616 | 271.9 kb | Distal (>10kb) Multiome | 733 | |
| chr3:126,356,733–126,358,455 | 273.5 kb | Distal (>10kb) Multiome | 534 |
Genomic view of the SLC41A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.