Predicted to enable magnesium ion transmembrane transporter activity. Involved in magnesium ion transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC41A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC41A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC41A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:104,953,332–104,953,606 | 4.7 kb | Proximal (<10kb) | 84 | |
| chr12:104,957,697–104,958,992 | 28 bp | At TSS Multiome | 811 | |
| chr12:104,986,118–104,986,938 | 28.0 kb | Distal (>10kb) Multiome | 665 | |
| chr12:105,083,642–105,085,161 | 126.3 kb | Distal (>10kb) Multiome | 490 | |
| chr12:105,107,164–105,108,312 | 149.4 kb | Distal (>10kb) Multiome | 1033 | |
| chr12:105,235,605–105,236,419 | 277.8 kb | Distal (>10kb) Multiome | 802 |
Genomic view of the SLC41A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.