Enables magnesium:sodium antiporter activity. Involved in cellular response to magnesium ion; intracellular magnesium ion homeostasis; and magnesium ion transmembrane transport. Located in basolateral plasma membrane. Part of protein-containing complex. Implicated in nephronophthisis. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC41A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC41A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC41A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:205,528,647–205,529,482 | 284.0 kb | Distal (>10kb) Multiome | 390 | |
| chr1:205,543,280–205,544,028 | 269.6 kb | Distal (>10kb) Multiome | 371 | |
| chr1:205,591,729–205,592,393 | 221.1 kb | Distal (>10kb) Multiome | 624 | |
| chr1:205,631,034–205,632,587 | 181.4 kb | Distal (>10kb) Multiome | 1054 | |
| chr1:205,670,539–205,671,380 | 142.4 kb | Distal (>10kb) Multiome | 189 | |
| chr1:205,679,697–205,680,913 | 132.7 kb | Distal (>10kb) Multiome | 568 | |
| chr1:205,706,859–205,707,298 | 106.3 kb | Distal (>10kb) Multiome | 145 | |
| chr1:205,748,908–205,750,848 | 63.6 kb | Distal (>10kb) Multiome | 1074 | |
| chr1:205,774,834–205,775,616 | 37.8 kb | Distal (>10kb) Multiome | 637 | |
| chr1:205,810,597–205,810,769 | 2.4 kb | Proximal (<10kb) | 36 | |
| chr1:205,812,462–205,814,100 | 136 bp | At TSS Multiome | 693 | |
| chr1:205,849,914–205,850,368 | 37.0 kb | Distal (>10kb) Multiome | 143 | |
| chr1:205,918,766–205,919,275 | 105.9 kb | Distal (>10kb) Multiome | 284 |
Genomic view of the SLC41A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.