The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for SLC37A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC37A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC37A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:42,218,772–42,219,352 | 294.8 kb | Distal (>10kb) Multiome | 258 | |
| chr21:42,234,400–42,235,305 | 278.9 kb | Distal (>10kb) Multiome | 427 | |
| chr21:42,495,806–42,497,032 | 17.4 kb | Distal (>10kb) Multiome | 588 | |
| chr21:42,513,219–42,514,906 | 248 bp | At TSS Multiome | 484 | |
| chr21:42,593,112–42,593,723 | 79.6 kb | Distal (>10kb) Multiome | 299 | |
| chr21:42,652,544–42,654,689 | 139.8 kb | Distal (>10kb) Multiome | 510 |
Genomic view of the SLC37A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.